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Series GSE253484 Query DataSets for GSE253484
Status Public on Jan 31, 2024
Title Idd5 favours robust neonatal development of highly autoreactive regulatory T cells in the NOD mouse
Organism Mus musculus
Experiment type Genome variation profiling by array
Summary Regulatory T lymphocytes expressing the transcription factor Foxp3 (Treg) play an important role in the prevention of autoimmune diseases and other immunopathologies. Aberrations in Treg-mediated immunosuppression are therefore thought to be involved in the development of autoimmune pathologies but few have been documented. Recent reports indicated a central role for Treg developing during the neonatal period in the prevention of autoimmune pathology. We therefore investigated the development of Treg in neonatal NOD mice, an important animal model for autoimmune type 1 diabetes. Surprisingly, we found that, as compared to seven other commonly studied inbred mouse-strains, in neonatal NOD mice exceptionally large proportions of developing Treg express high levels of GITR and PD-1. The latter phenotype was previously associated with high Treg-autoreactivity in C57BL/6 mice, which we here confirm for NOD animals. Proportions of newly developing GITRhighPD-1+ Treg rapidly drop during the first week of age. A genome-wide genetic screen indicated involvement of several diabetes susceptibility loci in this trait. Analysis of a congenic mouse-strain confirmed that Idd5 contributes to the genetic control of GITRhighPD-1+ Treg-development in neonates. Our data thus demonstrate an intriguing and paradoxical correlation between an idiosyncrasy in Treg development in NOD mice and their susceptibility to type 1 diabetes.
 
Overall design We therefore investigated the development of Treg in neonatal NOD mice, an important animal model for autoimmune type 1 diabetes. Surprisingly, we found that, as compared to seven other commonly studied inbred mouse-strains, in neonatal NOD mice exceptionally large proportions of developing Treg express high levels of GITR and PD-1.
 
Contributor(s) Santamaria JC, Vuillier S, Galindo-Albarrán A, Castan S, Detraves C, Joffre OP, Romagnoli P, an Meerwijk JM
Citation(s) 38404576
Submission date Jan 17, 2024
Last update date Mar 07, 2024
Contact name Joost van Meerwijk
E-mail(s) Joost.van-Meerwijk@inserm.fr
Phone 0562748381
Organization name INSERM
Department U1043
Lab Joost van Meerwijk Eq1
Street address CHU Purpan – BP 3028
City Toulouse
State/province HG
ZIP/Postal code 31024
Country France
 
Platforms (1)
GPL34100 GGP Mouse (GIGA-MUGA)
Samples (96)
GSM8021443 A1
GSM8021444 B1
GSM8021445 C1
Relations
BioProject PRJNA1065879

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE253484_RAW.tar 223.1 Mb (http)(custom) TAR (of IDAT)
Raw data provided as supplementary file
Processed data included within Sample table

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