|
| Status |
Public on Nov 05, 2010 |
| Title |
Prostate specific Pten deletion, Pten-Smad4 deletion, and Pten-p53 deletion |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We used microarrays to detail the global gene expression and identified differentially expressed gene list between wild-type anterior prostates and Ptenpc-/- anterior prostates, Ptenpc-/-Smad4pc-/- and Ptenpc-/- anterior prostates, Ptenpc-/-p53pc-/- and Ptenpc-/- anterior prostates at 15 weeks of age.
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| |
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| Overall design |
Prostate-specific Pten deletion (Ptenpc-/-) results in prostate intraepithelial neoplasia (PIN) which, following a long latency, can progress to high-grade adenocarcinoma, albeit with minimally invasive and metastatic features. To understand this feeble progression phenotype, we conducted transcriptome comparison of five Ptenpc-/- PIN relative to three wild-type anterior prostate. Moreover, Ptenpc-/-Smad4pc-/- progress to metastasis, while Ptenpc-/-p53pc-/- not progress to metastasis. To understand this phenotype difference, we conducted transcriptome comparison of five Ptenpc-/-Smad4pc-/-to five Ptenpc-/- prostate tumor, and three Ptenpc-/-p53pc-/- to five Ptenpc-/- tumor.
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| Contributor(s) |
Xiao Y, Ding Z |
| Citation(s) |
21289624 |
| |
| Submission date |
Nov 04, 2010 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Zhihu Ding |
| E-mail(s) |
jeff_ding@dfci.harvard.edu
|
| Phone |
617-632-5226
|
| Fax |
617-632-6069
|
| Organization name |
Dana-Farber Cancer Institute
|
| Department |
Medical Oncology
|
| Lab |
Ronald A. DePinho Lab
|
| Street address |
44 Binney Street
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (16)
|
| GSM617881 |
wild-type anterior prostate Q6515AP |
| GSM617882 |
wild-type anterior prostate Q6516AP |
| GSM617883 |
wild-type anterior prostate Q6424AP_redo |
| GSM617884 |
Prostate-specific Pten deletion anterior prostate tumor M5852 |
| GSM617885 |
Prostate-specific Pten deletion anterior prostate tumor M5853 |
| GSM617886 |
Prostate-specific Pten deletion anterior prostate tumor M6167 |
| GSM617887 |
Prostate-specific Pten deletion anterior prostate tumor M7802 |
| GSM617888 |
Prostate-specific Pten deletion anterior prostate tumor M7805 |
| GSM617889 |
Prostate-specific Pten and Smad4 deletion anterior prostate tumor A6291 |
| GSM617890 |
Prostate-specific Pten and Smad4 deletion anterior prostate tumor A6295 |
| GSM617891 |
Prostate-specific Pten and Smad4 deletion anterior prostate tumor A6296 |
| GSM617892 |
Prostate-specific Pten and Smad4 deletion anterior prostate tumor A5755 |
| GSM617893 |
Prostate-specific Pten and Smad4 deletion anterior prostate tumor A7907 |
| GSM617894 |
Prostate-specific Pten and p53 deletion anterior prostate tumor 11452A0 |
| GSM617895 |
Prostate-specific Pten and p53 deletion anterior prostate tumor 11526A0-REDO |
| GSM617896 |
Prostate-specific Pten and p53 deletion anterior prostate tumor 11527A0-REDO |
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| Relations |
| BioProject |
PRJNA134477 |
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