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Series GSE249684 Query DataSets for GSE249684
Status Public on Sep 11, 2024
Title Unraveling the Phenotypic States of Human innate-like T Cells in thymus and blood: Insights from Single-Cell Transcriptomics
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The "innate-like" T cell compartment, known as Tinn, encompasses a diverse group of T cells that straddle the boundary between innate and adaptive immunity. We explored the transcriptional landscape of Tinn compared to conventional T cells (Tconv) in the human thymus and blood using scRNA sequencing
 
Overall design iNKT cells, MAIT, gd T cells, CD4 SP and CD8 SP T cells were isolated from pediatric human thymus of adult blood by fluorescence-activated cell sorting (FACS) using appropriate tetramers, anti-TCRalpha chains and cell surface antibodies.
 
Contributor(s) Laurent G, Hannah M, Brunetti T
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Submission date Dec 08, 2023
Last update date Sep 12, 2024
Contact name Tonya Brunetti
E-mail(s) tonya.brunetti@cuanschutz.edu
Organization name University of Colorado Anschutz Medical Campus
Department Immunology and Microbiology
Street address 12800 East 19th Avenue
City Aurora
State/province CO
ZIP/Postal code 80045
Country USA
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (7)
GSM7957346 CD4_CD8_Thymus_A
GSM7957347 CD4_CD8_NKT_MAIT_Thymus_B
GSM7957348 CD4_CD8_NKT_MAIT_GD_Thymus_C
Relations
BioProject PRJNA1050192

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE249684_RAW.tar 141.9 Mb (http)(custom) TAR (of CSV)
GSE249684_metadata.csv.gz 111.6 Mb (ftp)(http) CSV
GSE249684_rawcounts.h5 134.9 Mb (ftp)(http) H5
GSE249684_seurat_object.rds.gz 442.0 Mb (ftp)(http) RDS
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Raw data are available in SRA

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