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Status |
Public on Sep 11, 2024 |
Title |
Unraveling the Phenotypic States of Human innate-like T Cells in thymus and blood: Insights from Single-Cell Transcriptomics |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
The "innate-like" T cell compartment, known as Tinn, encompasses a diverse group of T cells that straddle the boundary between innate and adaptive immunity. We explored the transcriptional landscape of Tinn compared to conventional T cells (Tconv) in the human thymus and blood using scRNA sequencing
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Overall design |
iNKT cells, MAIT, gd T cells, CD4 SP and CD8 SP T cells were isolated from pediatric human thymus of adult blood by fluorescence-activated cell sorting (FACS) using appropriate tetramers, anti-TCRalpha chains and cell surface antibodies.
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Contributor(s) |
Laurent G, Hannah M, Brunetti T |
Citation missing |
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Submission date |
Dec 08, 2023 |
Last update date |
Sep 12, 2024 |
Contact name |
Tonya Brunetti |
E-mail(s) |
tonya.brunetti@cuanschutz.edu
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Organization name |
University of Colorado Anschutz Medical Campus
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Department |
Immunology and Microbiology
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Street address |
12800 East 19th Avenue
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City |
Aurora |
State/province |
CO |
ZIP/Postal code |
80045 |
Country |
USA |
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Platforms (1) |
GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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Samples (7)
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Relations |
BioProject |
PRJNA1050192 |