|
| Status |
Public on Mar 01, 2024 |
| Title |
Corpora cavernosa fibroblasts mediate penile erection |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Penile erection is mediated by the corpora cavernosa, a trabecular-like vascular bed, which enlarges upon vasodilation, but its regulation is not completely understood. Here, we show that perivascular fibroblasts in the corpora cavernosa support vasodilation by reducing norepinephrine availability. We used scRNAseq to investigate fibroblast heterogeneity in the penis.
|
| |
|
| Overall design |
Slc1a3-derived cells were isolated from adult mouse penises using the Slc1a3CreERT;tdTomato line. Cells were sorted based on tdTomato expression in 384 well plates containing lysis buffer and subject to scRNAseq.
|
| |
|
| Contributor(s) |
Guimaraes E, Julien A, Göritz C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 06, 2023 |
| Last update date |
Mar 02, 2024 |
| Contact name |
Anais Julien |
| E-mail(s) |
anais.julien@ki.se
|
| Phone |
0677513326
|
| Organization name |
Karolinska Institutet
|
| Department |
CMB
|
| Lab |
Goritz
|
| Street address |
Solnavagen 9
|
| City |
Solna |
| State/province |
non-US Resident |
| ZIP/Postal code |
171 64 |
| Country |
Sweden |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (1) |
|
| Relations |
| BioProject |
PRJNA1049437 |
