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Series GSE249288 Query DataSets for GSE249288
Status Public on Apr 01, 2024
Title Cancer SLC6A6-mediated taurine uptake impairs CD8+ T cell antitumor immunity by upregulating immune checkpoints [mouse RNA-Seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Taurine is a supplement used to bolster immunity, but how taurine affects antitumor immunity remains largely unknown. We report that SLC6A6-mediated uptake of taurine by gastric cancer (GC) cells results in T cell exhaustion and cancer progression. SLC6A6 was correlated with GC aggressiveness and poor outcomes, and taurine uptake increased GC proliferation, survival, and cell motility. Taurine significantly increased CD8+ T cell infiltration and cytotoxic effector expression in GC tumors. Mechanistically, taurine deprivation in CD8+ T cells increased ER stress and the unfolded protein response, resulting in AT4 transcription, which acts as a switch for T cell exhaustion. SLC6A6 was transactivated by SP1 in GC cells, with a strong correlation between SP1 and SLC6A6 in GC patients. The SP1-SLC6A6 axis was triggered by chemotherapy. Our findings reveal that SLC6A6-mediated taurine consumption impacts immune evasion and propose that taurine supplementation might reinvigorate CD8+ T cell response and enhance therapy efficacy.
Overall design Single CD45+ immune cells were obtained from taurine-treated MFC tumors from 615 mice and compared to their counterparts in saline-treated tumors.
Contributor(s) Zhao X, Cao T
Citation(s) 38565142
Submission date Dec 04, 2023
Last update date Apr 11, 2024
Contact name Xiaodi Zhao
Organization name Xijing Hospital of Fourth Military Medical University
Department Xijing Hospital of Digestive Diseases
Lab State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases
Street address No.127 Changle West Road
City Xi'an
ZIP/Postal code 710032
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (6)
GSM7933096 Saline-1
GSM7933097 Saline-2
GSM7933098 Saline-3
BioProject PRJNA1048446

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GSE249288_RAW.tar 633.5 Mb (http)(custom) TAR (of TAR)
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Raw data are available in SRA

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