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| Status |
Public on Jan 17, 2024 |
| Title |
YTHDF3 modulates the stability of Cbln1 mRNA by recruiting BTG2 and is implicated in the impaired cognition of prenatal hypoxia offspring |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The “Fetal Origins of Adult Disease (FOAD)” hypothesis holds that adverse factors during pregnancy can increase the risk of chronic diseases in offspring. Here, we investigated the effects of prenatal hypoxia (PH) on brain structure and function in adult offspring and explored the role of the N6-methyladenosine (m6A) pathway. The results suggest that abnormal cognition in PH offspring may be related to dysregulation of the m6A pathway, specifically increased levels of YTHDF3 in the hippocampus. YTHDF3 interacts with BTG2 and is involved in the decay of Cbln1 mRNA, leading to the down-regulation of Cbln1 expression. Deficiency of Cbln1 may contribute to abnormal synaptic function, which in turn causes cognitive impairment in PH offspring. This study provides new scientific clues for understanding the mechanisms of impaired cognition in PH offspring and provides a theoretical basis for the treatment of cognitive impairment in offspring exposed to PH.
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| Overall design |
To investigated the effects of prenatal hypoxia (PH) on brain structure and function in adult offspring , we established a PH modle of C57BL/6J mice. Then performed and comparative gene expression profiling analysis using data obtained from RNA-seq of control and PH offspring.
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| Contributor(s) |
Lu L, Sun M |
| Citation(s) |
38205248 |
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| Submission date |
Dec 01, 2023 |
| Last update date |
Jan 17, 2024 |
| Contact name |
Miao Sun |
| E-mail(s) |
miaosun33@suda.edu.cn
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| Organization name |
Institute for Fetology, The First Affiliated Hospital of Soochow University
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| Street address |
The First Affiliated Hospital of Soochow University
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| City |
soochow |
| ZIP/Postal code |
215006 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (10)
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| GSM7927477 |
hippocampus, offspring of control pregnancy, C57BL/6J, biol rep 1 |
| GSM7927478 |
hippocampus, offspring of control pregnancy, C57BL/6J, biol rep 2 |
| GSM7927479 |
hippocampus, offspring of control pregnancy, C57BL/6J, biol rep 3 |
| GSM7927480 |
hippocampus, offspring of control pregnancy, C57BL/6J, biol rep 4 |
| GSM7927481 |
hippocampus, offspring of control pregnancy, C57BL/6J, biol rep 5 |
| GSM7927482 |
hippocampus, offspring of prenatal hypoxia, C57BL/6J, biol rep 1 |
| GSM7927483 |
hippocampus, offspring of prenatal hypoxia, C57BL/6J, biol rep 2 |
| GSM7927484 |
hippocampus, offspring of prenatal hypoxia, C57BL/6J, biol rep 3 |
| GSM7927485 |
hippocampus, offspring of prenatal hypoxia, C57BL/6J, biol rep 4 |
| GSM7927486 |
hippocampus, offspring of prenatal hypoxia, C57BL/6J, biol rep 5 |
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| Relations |
| BioProject |
PRJNA1047547 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE249147_read_counts.txt.gz |
560.6 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
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