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Series GSE247619 Query DataSets for GSE247619
Status Public on Jun 01, 2024
Title Histone methyltransferase SETDB1 silenced SINE B2 retrotransposons and maintained mitotic cell cycle of neural progenitor cells (WGBS)
Organism Mus musculus
Experiment type Methylation profiling by high throughput sequencing
Summary Short interspersed nuclear element (SINE) B2 are a type of DNA retrotransposon that organize three-dimensional genome during development. Containing binding sites for CCCTC-binding factor (CTCF), SINE_B2 serve as domain boundary elements that control chromatin state and initiate transcription of critical developmental genes. However, it is still unclear how SINE_B2 are regulated during neurodevelopment. Our findings indicate novel mechanisms that modulate critical DNA retrotransposon activity, maintain chromosome conformation and contribute to central nervous system development.
 
Overall design Examination of whole genome DNA methylation in wildtype (WT) and Setdb1-KO (KO) neural progenitor cells.
 
Contributor(s) Sun D, Jiang Y
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Nov 13, 2023
Last update date Jun 03, 2024
Contact name Yan Jiang
E-mail(s) yan_jiang@fudan.edu.cn
Organization name Fudan University
Department Institutes of Brain Science
Street address 131 Dongan rd
City Shanghai
ZIP/Postal code 200032
Country China
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM7898085 WT_NPC_WGBS_Rep1
GSM7898086 WT_NPC_WGBS_Rep2
GSM7898087 KO_NPC_WGBS_Rep1
This SubSeries is part of SuperSeries:
GSE247620 Histone methyltransferase SETDB1 silenced SINE B2 retrotransposons and maintained mitotic cell cycle of neural progenitor cells
Relations
BioProject PRJNA1039830

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE247619_RAW.tar 691.4 Mb (http)(custom) TAR (of COV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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