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Status |
Public on Jun 01, 2024 |
Title |
Histone methyltransferase SETDB1 silenced SINE B2 retrotransposons and maintained mitotic cell cycle of neural progenitor cells (ChIP-Seq) |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
Short interspersed nuclear element (SINE) B2 are a type of DNA retrotransposon that organize three-dimensional genome during development. Containing binding sites for CCCTC-binding factor (CTCF), SINE_B2 serve as domain boundary elements that control chromatin state and initiate transcription of critical developmental genes. However, it is still unclear how SINE_B2 are regulated during neurodevelopment. Our findings indicate novel mechanisms that modulate critical DNA retrotransposon activity, maintain chromosome conformation and contribute to central nervous system development.
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Overall design |
Examination of histone H3K9me3 modification and CTCF binding in wildtype (WT) and Setdb1-KO (KO) neural progenitor cells.
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Contributor(s) |
Sun D, Jiang Y |
Citation(s) |
38961490 |
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Submission date |
Nov 13, 2023 |
Last update date |
Aug 01, 2024 |
Contact name |
Yan Jiang |
E-mail(s) |
yan_jiang@fudan.edu.cn
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Organization name |
Fudan University
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Department |
Institutes of Brain Science
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Street address |
131 Dongan rd
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City |
Shanghai |
ZIP/Postal code |
200032 |
Country |
China |
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Platforms (1) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (12)
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This SubSeries is part of SuperSeries: |
GSE247620 |
Histone methyltransferase SETDB1 silenced SINE B2 retrotransposons and maintained mitotic cell cycle of neural progenitor cells |
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Relations |
BioProject |
PRJNA1039826 |