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| Status |
Public on Nov 05, 2023 |
| Title |
Transcriptome analysis of J558 allograft mouse model treated with the CDC7-specific inhibitor TAK-931 [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To comprehensively evaluate in vivo inflammatory effects of TAK-931 in tumor microenvironment, RNA-seq was conducted in the J558 allograft mouse model. The GSEA revealed significant enrichment of inflammatory hallmarks in TAK-931-treated allografts. Metascape analyses also visualized that the network modules of the inflammatory signaling pathways were predominantly enriched.
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| Overall design |
The J558-allografted BALB/c female mice were orally administered vehicle or TAK-931 at 60 mg/kg, QD for 6 days. Vehicle and TAK-931 treated J558 allografts were analyzed using two independent samples.
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| Contributor(s) |
Kashima Y, Morita TY, Yoshiya M, Ohashi A |
| Citation(s) |
37980406 |
| |
| Submission date |
Oct 10, 2023 |
| Last update date |
Dec 08, 2023 |
| Contact name |
Akihiro Ohashi |
| E-mail(s) |
aohashi@east.ncc.go.jp
|
| Phone |
+81-4-7133-1111
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| Organization name |
National Cancer Center Japan
|
| Department |
Exploratory Oncology Research and Clinical Center
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| Lab |
Division of Collaborative Research and Development
|
| Street address |
6-5-1 Kashiwanoha
|
| City |
Kashiwa |
| State/province |
Chiba |
| ZIP/Postal code |
2778577 |
| Country |
Japan |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA1026573 |
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