|
| Status |
Public on Nov 02, 2023 |
| Title |
Epidermal Growth Factor Receptor Activation is Essential for Kidney Fibrosis Development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We found that EGFR expression increased in interstitial myofibroblasts in human and mouse fibrotic kidneys. Selective EGFR deletion in the fibroblast/pericyte population inhibited interstitial fibrosis in response to unilateral ureteral obstruction, ischemia or nephrotoxins. We used single-nucleus RNA sequencing analysis to demonstrate the role of EGFR activation in UUO model.
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| Overall design |
Kidneys from both WT mice and FibEGFR-/- mice at day 1 and day 3 after UUO were used with kidneys of 3-5 mice from same group being combined for analysis.
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| |
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| Contributor(s) |
Harris R, Zhang M, Cao S, Wang Y |
| Citation(s) |
37963889 |
| |
| Submission date |
Oct 06, 2023 |
| Last update date |
Feb 01, 2024 |
| Contact name |
Yinqiu Wang |
| E-mail(s) |
yinqiu.wang@vumc.org
|
| Phone |
6153438471
|
| Organization name |
vumc
|
| Department |
medicine
|
| Lab |
harris
|
| Street address |
313 Harpeth view circle
|
| City |
Nashville |
| State/province |
TN |
| ZIP/Postal code |
37221 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (5)
|
|
| Relations |
| BioProject |
PRJNA1024998 |
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