GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE244839 Query DataSets for GSE244839
Status Public on Nov 02, 2023
Title Epidermal Growth Factor Receptor Activation is Essential for Kidney Fibrosis Development
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We found that EGFR expression increased in interstitial myofibroblasts in human and mouse fibrotic kidneys. Selective EGFR deletion in the fibroblast/pericyte population inhibited interstitial fibrosis in response to unilateral ureteral obstruction, ischemia or nephrotoxins. We used single-nucleus RNA sequencing analysis to demonstrate the role of EGFR activation in UUO model.
Overall design Kidneys from both WT mice and FibEGFR-/- mice at day 1 and day 3 after UUO were used with kidneys of 3-5 mice from same group being combined for analysis.
Contributor(s) Harris R, Zhang M, Cao S, Wang Y
Citation(s) 37963889
Submission date Oct 06, 2023
Last update date Feb 01, 2024
Contact name Yinqiu Wang
Phone 6153438471
Organization name vumc
Department medicine
Lab harris
Street address 313 Harpeth view circle
City Nashville
State/province TN
ZIP/Postal code 37221
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (5)
GSM7830644 9099rh9
GSM7830645 9099rh11
GSM7830646 9099rh12
BioProject PRJNA1024998

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE244839_RAW.tar 1.6 Gb (http)(custom) TAR (of MTX, TSV)
SRA Run SelectorHelp
Raw data are available in SRA

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap