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| Status |
Public on Jan 11, 2024 |
| Title |
Airway Microfold (M) Cells Emerge in the Post-IAV Lung |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Airway cell fates are altered during repair and regeneration following lung injury. Here we survey mouse airway epithelium using single nucleus RNA-sequencing after influenza (PR8) infection and uncovered the emergence of Microfold (M) cells in the post-IAV intrapulmonary lung. These pulmonary M cells share expression signatures with the better-characterized intestinal M cells. Furthermore, similar to intestinal M cells that function by overlying lymphoid follicles in Peyer’s Patches, the post-IAV pulmonary M cells are enriched over bronchus associated lymphoid tissue (BALT), suggestive an interactive relationship.
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| Overall design |
single nucleus RNA-seq from lineage labelled airway cells (Sox2-creER;SUN1-GFP) from control and 25 days post PR8 (IAV) infection
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| Contributor(s) |
Barr J, Xu L, Verheyden J, Sun X |
| Citation(s) |
38127584 |
| |
| Submission date |
Sep 28, 2023 |
| Last update date |
Jan 12, 2024 |
| Contact name |
Xin Sun |
| Organization name |
University of California San Diego
|
| Street address |
Cellular and Molecular Medicine East 1087, 9500 Gilman Drive
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| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92093 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA1022055 |
