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Series GSE244095 Query DataSets for GSE244095
Status Public on Sep 29, 2023
Title Antiepileptic medication induces homeostatic synaptic plasticity in pyramidal neurons of the adult human neocortex
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Homeostatic synaptic plasticity serves to maintain neuronal function within a dynamic range, compensating for perturbations in network activity. While coordinated structural and functional changes at synaptic sites play a crucial role in adaptive processes, the specific regulatory mechanisms and biological relevance of homeostatic plasticity in the human brain warrant further investigation. In this study, we investigated the effects of neural network silencing, achieved through pharmacological inhibition of voltage-gated sodium channels or glutamatergic neurotransmission – common targets of antiepileptic medication – on functional and structural properties of murine and human cortical tissue. Using mouse entorhino-hippocampal tissue cultures, acute slices of adult mice, and human brain tissue, we characterize homeostatic synaptic plasticity across models, brain regions, and species. Our findings demonstrate local homeostatic synaptic plasticity in the adult human neocortex, highlighting the potential effects of antiepileptic medication in brain regions unaffected by the primary diseases, which might represent a mechanism for neuropsychiatric effects linked to these medications and increased seizure susceptibility upon discontinuation of antiepileptic medication.
 
Overall design Comparative gene expression profiling analysis of RNA-seq data in different brain regions across species to decipher the effects of pharmacological activity deprivation in neural circuits.
 
Contributor(s) Lenz M, Kruse P, Eichler A, Straehle J, Hemeling H, Stöhr P, Beck J, Vlachos A
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Submission date Sep 26, 2023
Last update date Sep 29, 2023
Contact name Maximilian Lenz
E-mail(s) lenz.maximilian@mh-hannover.de
Organization name Hannover Medical School
Department Institute of Neuroanatomy and Cell Biology
Street address Carl-Neuberg-Straße 1
City Hannover
ZIP/Postal code 30625
Country Germany
 
Platforms (2)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (20)
GSM7806569 Human Neocortex, AED-1, biol rep 1
GSM7806570 Human Neocortex, AED-2, biol rep 2
GSM7806571 Human Neocortex, AED-3, biol rep 3
Relations
BioProject PRJNA1021222

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Supplementary file Size Download File type/resource
GSE244095_RAW.tar 5.1 Mb (http)(custom) TAR (of TXT)
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Raw data are available in SRA

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