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| Status |
Public on Sep 29, 2010 |
| Title |
Comparison of copy number variations between wildtype and BCL6 knockout BCR-ABL1-driven acute lymphoblastic leukemia |
| Organism |
Mus musculus |
| Experiment type |
Genome variation profiling by genome tiling array
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| Summary |
This comparative genomic hybridization (CGH) study investigated the effect of BCL6 on clonal evolution in BCR-ABL1-driven acute lymphoblastic leukemia (ALL). The frequencies of copy number alterations in BCR-ABL1-transformed BCL6+/+ and BCL6-/- leukemias were determined.
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| Overall design |
Three BCR-ABL1-transformed BCL6+/+ and BCL6-/- ALL samples derived from mice were maintained for 4 month in cell culture and were subjected to CGH analysis. As control samples, normal untransformed splenoytes were used.
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| Contributor(s) |
Duy C, Hurtz C, Cerchietti L, Klemm L, Swaminathan S, Shojaee S, Ci W, Geng H, Braig M, Hofmann W, Koeffler HP, Yu JJ, Nahar R, Kweon S, Hennighausen L, Herzog S, Jumaa H, Groffen J, Heisterkamp N, Ye BH, Melnick AM, Müschen M |
| Citation(s) |
21593872 |
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| Submission date |
Sep 28, 2010 |
| Last update date |
Mar 22, 2012 |
| Contact name |
Markus Müschen |
| E-mail(s) |
mmuschen@chla.usc.edu
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| Phone |
+ 1 323 361 5592
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| Fax |
+1 323 361 1516
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| URL |
http://www.lymphocytes.de/
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| Organization name |
University of Southern California
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| Department |
Childrens Hospital Los Angeles
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| Lab |
Müschen Lab
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| Street address |
4650 Sunset Blvd
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| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90027 |
| Country |
USA |
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| Platforms (1) |
| GPL10989 |
NimbleGen Mouse CGH 3x720K Whole-Genome Tiling Array (Build MM9) [080603_MM9_WG_CGH_HX3] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA132953 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE24400_RAW.tar |
354.6 Mb |
(http)(custom) |
TAR (of PAIR, TXT) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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