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| Status |
Public on Nov 02, 2023 |
| Title |
Runx3 restoration regresses K-Ras–activated mouse lung cancers and inhibits recurrence |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Comparision of the gene expression profiles of the RUNX3 Knock out and RUNX3 restored cells.
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| Overall design |
we obtained immortalized cell lines from KPRL/F-TAM(-) lung cancers (KPR-). Treatment of KPR- cell lines with 4-hydroxytamoxifen (4-OHT) restored Runx3, generating KPRrestored cell lines. We confirmed that Runx3 was restored at 8 h after 4-OHT treatment. To identify genes regulated by Runx3 in the K-Ras–activated lung cancer cells, we performed mRNA sequencing (RNA-seq) in KPR- cells and KPRrestored cells.
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| Contributor(s) |
Lee J, Lee Y, Lee J, Bae S |
| Citation(s) |
37887282 |
| |
| Submission date |
Sep 25, 2023 |
| Last update date |
Nov 03, 2023 |
| Contact name |
Jung-Won Lee |
| E-mail(s) |
jeongwon@chungbuk.ac.kr
|
| Phone |
82-10-4729-2261
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| Organization name |
Institute for Tumor Research
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| Department |
Department of Biochemistry, School of Medicine
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| Street address |
1, Chungdae-ro
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| City |
Cheongju |
| ZIP/Postal code |
28644 |
| Country |
South Korea |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA1020821 |
