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Series GSE243968 Query DataSets for GSE243968
Status Public on Nov 02, 2023
Title Runx3 restoration regresses K-Ras–activated mouse lung cancers and inhibits recurrence
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Comparision of the gene expression profiles of the RUNX3 Knock out and RUNX3 restored cells.
Overall design we obtained immortalized cell lines from KPRL/F-TAM(-) lung cancers (KPR-). Treatment of KPR- cell lines with 4-hydroxytamoxifen (4-OHT) restored Runx3, generating KPRrestored cell lines. We confirmed that Runx3 was restored at 8 h after 4-OHT treatment. To identify genes regulated by Runx3 in the K-Ras–activated lung cancer cells, we performed mRNA sequencing (RNA-seq) in KPR- cells and KPRrestored cells.
Contributor(s) Lee J, Lee Y, Lee J, Bae S
Citation(s) 37887282
Submission date Sep 25, 2023
Last update date Nov 03, 2023
Contact name Jung-Won Lee
Phone 82-10-4729-2261
Organization name Institute for Tumor Research
Department Department of Biochemistry, School of Medicine
Street address 1, Chungdae-ro
City Cheongju
ZIP/Postal code 28644
Country South Korea
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (2)
GSM7802501 RUNX3 knock out cells [KRP0h]
GSM7802502 RUNX3 restored cells [KRP16h]
BioProject PRJNA1020821

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GSE243968_RAW.tar 280.0 Kb (http)(custom) TAR (of TXT)
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