|
Status |
Public on Mar 04, 2024 |
Title |
Enhancer-activated RET confers protection against oxidative stress to the MLL-rearranged acute myeloid leukemia cells |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
|
Summary |
RET expression is upregulated in AML subtypes harboring genetic fusions of MLL-1 genes compared to age-matched healthy donors and other AML subtypes. In addition, we identify a novel epigenetic mechanism of RET overexpression in MLL-rearranged AML.
|
|
|
Overall design |
examination of chromatin accessibility in CD34 and MOLM13 cells
|
|
|
Contributor(s) |
Stephens KE, Choudhury SR |
Citation(s) |
38226414 |
|
Submission date |
Aug 25, 2023 |
Last update date |
Mar 04, 2024 |
Contact name |
Kimberly E Stephens |
E-mail(s) |
kestephens@uams.edu
|
Phone |
501-364-3307
|
Organization name |
University of Arkansas for Medical Sciences
|
Department |
Pediatrics
|
Street address |
13 Children's Way
|
City |
Little Rock |
State/province |
AR |
ZIP/Postal code |
72202 |
Country |
USA |
|
|
Platforms (1) |
GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
Samples (6)
|
|
Relations |
BioProject |
PRJNA1009434 |