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| Status |
Public on Feb 21, 2024 |
| Title |
Redox-sensitive high-mobility group box-1 isoforms contribute to liver fibrosis progression and resolution in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Since oxidative stress plays a major role in liver fibrosis and induces post-translational modifications of proteins, we hypothesized that redox-sensitive HMGB1 isoforms contribute to liver fibrosis progression and resolution. This study is significant because a rise in [H] HMGB1 could flag 'patient at risk', the presence of [O] HMGB1 could suggest 'disease in progress or active scarring', while the appearance of [SO3] HMGB1 could point at 'resolution under way'. The latter could be used as a readout for response to pharmacological intervention with anti-fibrotic agents.
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| Overall design |
RNA sequencing was performed in total liver at peak ALD. RAW264.7 cells were treated with BSA or complex ([O] HMGB1 + IL1β) for 6 hours.
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/37989401/
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| Contributor(s) |
Ge X, Nieto N |
| Citation(s) |
37989401 |
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| Submission date |
Aug 08, 2023 |
| Last update date |
Feb 21, 2024 |
| Contact name |
Xiaodong Ge |
| E-mail(s) |
xiaodongge650@gmail.com
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| Phone |
3476679182
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| Organization name |
The University of Illinois at Chicago
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| Department |
Pathology
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| Lab |
Liver
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| Street address |
909 South Wolcott Ave, COMRB 6140
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| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60612 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (20)
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| GSM7697455 |
Total liver, WT, Control diet, SD1-39 |
| GSM7697456 |
Total liver, WT, Alcohol diet, SD1-28 |
| GSM7697457 |
Total liver, WT, Alcohol diet, SD1-29 |
| GSM7697458 |
Total liver, WT, Alcohol diet, SD1-30 |
| GSM7697459 |
Total liver, WT, Alcohol diet, SD1-31 |
| GSM7697460 |
Total liver, Rage{delta}Mye, Control diet, XG3-3-1 |
| GSM7697461 |
Total liver, Rage{delta}Mye, Control diet, XG3-3-2 |
| GSM7697462 |
Total liver, Rage{delta}Mye, Control diet, XG3-3-3 |
| GSM7697463 |
Total liver, Rage{delta}Mye, Alcohol diet, XG3-4-1 |
| GSM7697464 |
Total liver, Rage{delta}Mye, Alcohol diet, XG3-4-2 |
| GSM7697465 |
Total liver, Rage{delta}Mye, Alcohol diet, XG3-4-3 |
| GSM7697466 |
RAW264.7, BSA, XG-1-1 |
| GSM7697467 |
RAW264.7, BSA, XG-1-2 |
| GSM7697468 |
RAW264.7, BSA, XG-1-3 |
| GSM7697469 |
RAW264.7, [O] HMGB1 + IL1β, XG-4-1 |
| GSM7697470 |
RAW264.7, [O] HMGB1 + IL1β, XG-4-2 |
| GSM7697471 |
RAW264.7, [O] HMGB1 + IL1β, XG-4-3 |
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| Relations |
| BioProject |
PRJNA1003497 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE240397_Liver__WT_and_Rage_mye__CD_or_EtOH.txt.gz |
819.0 Kb |
(ftp)(http) |
TXT |
| GSE240397_RAW264.7_with_Complex_or_BSA.txt.gz |
337.8 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
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