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Series GSE240101 Query DataSets for GSE240101
Status Public on Oct 01, 2023
Title Starving advanced prostate cancer cells by pharmacological gluose deprivation with a resveratrol trimer trans-Gnetin H [PDX]
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Prostate cancer is a unique disease from a metabolic perspective. Early stage localized prostate cancer does not typically display increased aerobic glycolysis (the Warburg effect), as seen in other malignancies. However, increasing evidence suggests that advanced prostate cancer exhibits the Warburg effect and displays high glucose uptake. We describe here that trans-gnetin H (TGH), a naturally-occurring resveratrol trimer extracted from Paeonia suffruticosa, displays significant anti-cancer effects in advanced prostate cancer cells xenografted PC-3 cells in vivo.TGH perturbs energy metabolism by blocking the availability of glucose and inducing profound metabolic and transcriptomic changes in prostate cancer cells as demonstrated by RNA-seq. C-MYC, a known driver oncogene in prostate cancer, is downregulated in TGH-treated cells. Our studies demonstrate the feasibility of targeting aerobic glucose metabolism in advanced prostate cancer and identify TGH as a potential therapeutic candidate.
Overall design PC3 xenograft tumor performed on athymic nude mice. 9 were treated with TGH. 9 were treated with vehicle control
Contributor(s) Yixuan G, Wiliiam O, Li W, Haocheng Y
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Submission date Aug 04, 2023
Last update date Oct 01, 2023
Contact name William Oh
Organization name Icahn School of Medicine at Mount Sinai
Street address 1 Gustave Levy Place
City New York
State/province New York
ZIP/Postal code 10029
Country USA
Platforms (1)
GPL19415 Illumina NextSeq 500 (Homo sapiens; Mus musculus)
Samples (18)
GSM7681527 PDX01, TGH-treated
GSM7681528 PDX02, TGH-treated
GSM7681529 PDX03, TGH-treated
This SubSeries is part of SuperSeries:
GSE240104 Starving advanced prostate cancer cells by pharmacological gluose deprivation with a resveratrol trimer trans-Gnetin H
BioProject PRJNA1002289

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE240101_count_human.txt.gz 654.6 Kb (ftp)(http) TXT
GSE240101_count_mouse.txt.gz 530.9 Kb (ftp)(http) TXT
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