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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 31, 2024 |
| Title |
Role of FGF23 and DMP1 in osteoblastogenesis in cultured BMSCs at single cell level |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Primary bone marrow cells from murine long bones were cultured in osteoblastic medium for 21 days. scRNAseq and differential expression analyzes were used to highlight the importance of FGF23 and DMP1 in osteoblastogenesis
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| Overall design |
mRNA profiles of differentiated Bone marrow stromal cells (BMSCs) from wild-type (WT) mice, mice with an osteocyte-specific deletion of Fgf23, harboring a floxed first exon of the Fgf23 gene and expressing a transgene containing a Cre recombinase sequence downstream of the Dmp1 promoter (Fgf23cKO), Dmp1 global knockout mice (Dmp1KO) and compound Dmp1KO/Fgf23cKO mice.
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| Contributor(s) |
Martin A, David V, Thomas JJ |
| Citation(s) |
37943605 |
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| Submission date |
Aug 01, 2023 |
| Last update date |
Feb 01, 2024 |
| Contact name |
Valentin David |
| E-mail(s) |
valentin.david@northwestern.edu
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| Phone |
13125034159
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| Organization name |
Northwestern University
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| Department |
Medicine
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| Lab |
David Lab
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| Street address |
320 E Superior Street
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| City |
Chicago |
| State/province |
Illinois |
| ZIP/Postal code |
60611 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (16)
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| GSM7674901 |
BMSCs, WT4 |
| GSM7674902 |
BMSCs, Fgf23cKO1 |
| GSM7674903 |
BMSCs, Fgf23cKO2 |
| GSM7674904 |
BMSCs, Fgf23cKO3 |
| GSM7674905 |
BMSCs, Fgf23cKO4 |
| GSM7674906 |
BMSCs, Dmp1KO1 |
| GSM7674907 |
BMSCs, Dmp1KO2 |
| GSM7674908 |
BMSCs, Dmp1KO3 |
| GSM7674909 |
BMSCs, Dmp1KO4 |
| GSM7674910 |
BMSCs, Dmp1KOFgf23cKO1 |
| GSM7674911 |
BMSCs, Dmp1KOFgf23cKO2 |
| GSM7674912 |
BMSCs, Dmp1KOFgf23cKO3 |
| GSM7674913 |
BMSCs, Dmp1KOFgf23cKO4 |
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| This SubSeries is part of SuperSeries: |
| GSE239830 |
Role of FGF23 and DMP1 in osteoblastogenesis |
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| Relations |
| BioProject |
PRJNA1001030 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE239828_ProcessedData.xlsx |
57.5 Kb |
(ftp)(http) |
XLSX |
| GSE239828_RAW.tar |
277.2 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
| Processed data provided as supplementary file |
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