|
| Status |
Public on Jul 24, 2023 |
| Title |
A novel CRISPR/Cas9 screening platform identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and anti-tumor immunity (Mouse RNA-Seq) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Investigation and validation of genes that regulate CXCL9 expression by RNA sequencing
|
| |
|
| Overall design |
Murine bone marrow was gene edited and then derived into macrophages using GM-CSF. Macrophages were stimulated with 1ng/mL IFNg for 17 hours.
|
| |
|
| Contributor(s) |
House I, Derrick E, Beavis P, Sek K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 21, 2023 |
| Last update date |
Jul 24, 2023 |
| Contact name |
Kevin C sek |
| E-mail(s) |
kevin.sek@petermac.org
|
| Phone |
0432960331
|
| Organization name |
Peter MacCallum Cancer Centre
|
| Department |
Cancer Immunology
|
| Lab |
Beavis Lab
|
| Street address |
305 Grattan Street
|
| City |
Melbourne |
| State/province |
VIC |
| ZIP/Postal code |
3000 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (12)
|
|
| This SubSeries is part of SuperSeries: |
| GSE237974 |
A novel CRISPR/Cas9 screening platform identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and anti-tumor immunity |
|
| Relations |
| BioProject |
PRJNA997317 |
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