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Series GSE237885 Query DataSets for GSE237885
Status Public on May 22, 2024
Title Gene expression profile at single nuclei level of cells from mouse hippocampus
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We performed single-nucleus RNA-seq and chromatin accessibility analyses (snRNA-seq and ATAC-seq) in the hippocampus of wild-type (WT) mice and mice carrying amyloid precursor protein knock-in mutations (APPNL-G-F) in response to chronic wheel-running exercise.
Overall design 8-week old female WT and APPNL-G-F mice were put into cages with running wheel for voluntary exercise for 10 weeks. Mice from 4 different conditions (WT_RT, WT_EX, APP_RT, APP_EX) were subjected to single nuclei RNA and ATAC sequencing.
Contributor(s) Wenbo L, Li Y, Sun Z
Citation(s) 38746443
Submission date Jul 20, 2023
Last update date May 23, 2024
Contact name Zheng Sun
Organization name Baylor College of Medicine
Street address 1329 Moursund St
City Houston
State/province Texas
ZIP/Postal code 77030
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (4)
GSM7655989 WT mouse without exercise, hippocampus, snRNAseq
GSM7655990 WT mouse with exercise, hippocampus, snRNAseq
GSM7655991 APPNL-G-F mouse without exercise, hippocampus, snRNAseq
This SubSeries is part of SuperSeries:
GSE237925 Single-nucleus multi-omics dissection of physical exercise effects on neurocognition
BioProject PRJNA996989

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Supplementary file Size Download File type/resource
GSE237885_RAW.tar 363.5 Mb (http)(custom) TAR (of MTX, TSV)
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Raw data are available in SRA
Processed data provided as supplementary file

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