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| Status |
Public on Jun 10, 2024 |
| Title |
Regulatory mechanism of Sox9 gene expression in chondrocytes [ATAC-seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
The transcription factor Sox9 (Sry-Related HMG-Box gene 9) is essential in chondrogenesis. The expression Sox9 is regulated by 1.5Mb long range genomic region in temporospatial manner and genome translocation or deletion which affect Sox9 expression cause campomelic dysplasia (CD), characterized by skeletal malformations. Although functional mechanism of Sox9 are well studied so far, regulatory mechanism of Sox9 expression and its related enhancer in chondrocytes are largely remains to be elucidated. The purpose of this study is to identify Sox9 enhancers in chondrocytes
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| |
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| Overall design |
ATAC-seq
|
| |
|
| Contributor(s) |
Kobayashi S, Hata K |
| Citation(s) |
38855864 |
| |
| Submission date |
Jul 20, 2023 |
| Last update date |
Sep 09, 2024 |
| Contact name |
Kenji Hata |
| E-mail(s) |
hata.kenji.dent@osaka-u.ac.jp
|
| Phone |
+81-6-6879-2887
|
| Organization name |
Osaka University graduate school of dentistry
|
| Department |
Biochemistry
|
| Street address |
1-8 Yamadaoka
|
| City |
Suita |
| State/province |
Osaka |
| ZIP/Postal code |
565-0871 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE237889 |
Regulatory mechanism of Sox9 gene expression in chondrocytes |
|
| Relations |
| BioProject |
PRJNA996984 |
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