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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 03, 2024 |
| Title |
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer |
| Organism |
Mus musculus |
| Experiment type |
Other
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| Summary |
Keap1 mutant lung tumors were injected into mice and once lung tumors formed the mice were treated with anti-PD1, DRP-104, or the combination of the drugs. Immune cells and tumor cells were isolated from the lungs and ExCITE-seq was performed.
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| Overall design |
2 mice (G1 vs G2) per treatment arm: Isotype + Vehicle (HT4), DRP-104 + Isotype (HT2), anti-PD1 + Vehicle (HT3), and DRP-104 + anti-PD1 (HT1). After 5 days of treatment, immune and tumor cells were analyzed by ExCITE-seq with libraries for gene expression, ADT, and TCR
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| Contributor(s) |
Pillai R, LeBoeuf S, Hao Y, Tsirigos A, Koralov S, Papagiannakopoulos T |
| Citation(s) |
38536921 |
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| Submission date |
Jul 17, 2023 |
| Last update date |
Apr 04, 2024 |
| Contact name |
Alireza Khodadadi-Jamayran |
| Organization name |
New York University, NYU Langone Medical Center
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| Department |
Division of Advanced Research Technologies (DART)
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| Lab |
Applied Bioinformatics Laboratories (ABL)
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| Street address |
550 1st Ave, MSB 304
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| City |
New York City |
| State/province |
NY |
| ZIP/Postal code |
10016 |
| Country |
USA |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA995781 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE237592_RAW.tar |
216.2 Mb |
(http)(custom) |
TAR (of CSV, MTX, TSV) |
| GSE237592_README.txt |
839 b |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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