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Series GSE23540 Query DataSets for GSE23540
Status Public on May 03, 2013
Title Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors
Organism Homo sapiens
Experiment type Genome variation profiling by genome tiling array
Summary Thymic epithelial tumors are a group of neoplasms with heterogeneous histological features and clinical behavior. The identification of markers useful to predict patient prognosis and molecular targets for therapies is limited by a very little understanding of the biology of these neoplasms. We evaluated the copy number (CN) aberrations of genes involved in normal thymus development in thymic epithelial tumors, following the intriguing idea that the ectopic deregulation of genes relevant for proliferation and differentiation of embryonic cells, can contribute to tumor growth. Frequent CN losses of FOXC1 were observed in more aggressive tumors and correlated with a reduced protein expression; tumors negative for FOXC1 expression were associated with a shorter time to progression. In addition, FOXC1 showed tumor suppressor activity in in-vitro models. Our data indicate that FOXC1 loss can identify a group of thymic epithelial tumors with poor prognosis, possibly because its tumor suppressor properties.
Overall design Two color array CGH of a series of 59 thymic epithelial tumors plus evaluation of 2 thymic carcinoma cell lines and one thymoma B1 cell line.
Contributor(s) Petrini I, Wang Y, Zucali PA, Lee HS, Trung P, Voeller D, Meltzer PS, Giaccone G
Citation(s) 23444221, 22825469
Submission date Aug 10, 2010
Last update date May 04, 2013
Contact name Iacopo Petrini
Phone 00393428566432
Organization name Pisa University
Street address Via Roma 67
City Pisa
ZIP/Postal code 56100
Country Italy
Platforms (2)
GPL4093 Agilent-014698 Human Genome CGH Microarray 105A (G4412A)
GPL10123 Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version)
Samples (62)
GSM577145 I-Thy 004
GSM577146 I-Thy 007
GSM577147 I-Thy 020
BioProject PRJNA131831

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23540_RAW.tar 1003.6 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data provided as supplementary file

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