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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Aug 02, 2024 |
| Title |
Aging- and Alcohol-Associated Spatial Transcriptomic Signature in Mouse Acute Pancreatitis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
The rapidly aging population has an increased alcohol use, resulting in increased risk and mortality of alcohol-associated acute pancreatitis in the elderly population. We established an aging- and alcohol-associated acute pancreatitis mouse model and applied spatial transcriptomics to profile heterogenous tissue composition in the mouse pancreas and the associated gene expression. By comparing with the young cohorts, our analysis has revealed the key differentially expressed genes in functional tissue compartments for understanding the mechanisms and developing targeted therapeutic strategies.
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| Overall design |
Pancreatic formalin-fixed paraffin-embedded tissue sections from four C57BL/6 male mice (2 young and 2 aging) with acute pancreatitis induced by alcohol liquid diet feeding and cerulein injection were analyzed using spatial transcriptomics.
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| Contributor(s) |
Tindall R, Yang Y, Cao Y, Zheng J, Ko T |
| Citation(s) |
38940937 |
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| Submission date |
Jun 20, 2023 |
| Last update date |
Aug 03, 2024 |
| Contact name |
Wenbo Chen |
| E-mail(s) |
Wenbo.Chen@uth.tmc.edu
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| Organization name |
The University of Texas Health Science Center at Houston
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| Street address |
7000 Fannin Street
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| City |
Houston |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA985604 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE235247_RAW.tar |
58.2 Mb |
(http)(custom) |
TAR (of CSV, H5, JPG, JSON, PNG) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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