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| Status |
Public on Feb 19, 2024 |
| Title |
Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We performed high-throughput profiling of gene expression in the anterior paraventricular nucleus of thalamus of stress-vulnerable BALB/c mice subjected to social defeat stress. BALB/c mice were subjected to 5-day of social defeat stress and then injected with saline or (2S,6S)-HNK. Seven days after the drug injection, mice were euthanized for tissue collection. We then conducted the transcriptomics analysis. Our study provided insights into the understanding of the molecular mechanisms underlying the sustained antidepresssant effects of (2S,6S)-HNK.
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| Overall design |
BALB/c mice were subjected to 5-day of social defeat stress (smSDS). Total 3 groups were set up: non-stressed (NS_Saline), social defeat stres swith saline (smSDS_Saline), and smSDS with (2S,6S)-HNK (smSDS_SHNK). Three replicates were used for each group.
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| Contributor(s) |
Uchida S |
| Citation(s) |
38377990 |
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| Submission date |
May 23, 2023 |
| Last update date |
May 20, 2024 |
| Contact name |
Shusaku Uchida |
| E-mail(s) |
uchida.shusaku.3n@kyoto-u.ac.jp
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| Organization name |
Kyoto University
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| Street address |
53 Kawaharamachi, Sakyo-ku
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| City |
Kyoto |
| State/province |
Kyoto |
| ZIP/Postal code |
606-8507 |
| Country |
Japan |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (9)
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| GSM7413248 |
BALB mice, stress_saline, Rep1 |
| GSM7413249 |
BALB mice, stress_saline, Rep2 |
| GSM7413250 |
BALB mice, stress_saline, Rep3 |
| GSM7413251 |
BALB mice, stress_(2S,6S)-HNK, Rep1 |
| GSM7413252 |
BALB mice, stress_(2S,6S)-HNK, Rep2 |
| GSM7413253 |
BALB mice, stress_(2S,6S)-HNK, Rep3 |
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| Relations |
| BioProject |
PRJNA975492 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE233226_ReadCount.txt.gz |
359.3 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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