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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 13, 2023 |
| Title |
Mutations in CHEK2 affect the tumor immune microenvironment and increase the response to PD-1 inhibitor therapy |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To elucidate whether CHEK2 mutations has a similar effect on the tumor microenvironment and response to immune checkpoint blockade therapy as mutations in POLE, we performed RNA-seq analysis of tumor tissues of mice receiving PBS or anti-PD-1 therapy to compare the gene expression profiles.
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| Overall design |
RNA-seq was performed on CT26 tumors tissues of mice in POLE-mutant and vector cells which received PBS(N=5) or anti-PD-1(N=5).
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| Contributor(s) |
Xu P |
| Citation(s) |
38097135 |
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| Submission date |
May 22, 2023 |
| Last update date |
Feb 12, 2024 |
| Contact name |
Pingping Xu |
| E-mail(s) |
xupingpingapple@sina.cn
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| Organization name |
Shanghai Institute of Digestive Diseases, Renji Hospital, Shanghai Jiao-Tong University School of Medicine
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| Street address |
145 Middle Shandong Road
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| City |
Shanghai |
| ZIP/Postal code |
200001 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (20)
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| GSM7405503 |
CT26-vector+PBS, 183 |
| GSM7405504 |
CT26-vector+PBS, 155 |
| GSM7405505 |
CT26-vector+anti-PD-1, M40 |
| GSM7405506 |
CT26-vector+anti-PD-1, M562 |
| GSM7405507 |
CT26-vector+anti-PD-1, 181 |
| GSM7405508 |
CT26-vector+anti-PD-1, M60 |
| GSM7405509 |
CT26-vector+anti-PD-1, 176 |
| GSM7405510 |
CT26 POLE-mutant+PBS, M97 |
| GSM7405511 |
CT26 POLE-mutant+PBS, M44 |
| GSM7405512 |
CT26 POLE-mutant+PBS, M3 |
| GSM7405513 |
CT26 POLE-mutant+PBS, 223 |
| GSM7405514 |
CT26 POLE-mutant+PBS, 205 |
| GSM7405515 |
CT26 POLE-mutant+anti-PD-1, M59 |
| GSM7405516 |
CT26 POLE-mutant+anti-PD-1, M82 |
| GSM7405517 |
CT26 POLE-mutant+anti-PD-1, 156 |
| GSM7405518 |
CT26 POLE-mutant+anti-PD-1, 203 |
| GSM7405519 |
CT26 POLE-mutant+anti-PD-1, 217 |
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| Relations |
| BioProject |
PRJNA975507 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE233162_RAW.tar |
5.7 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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