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Series GSE232391 Query DataSets for GSE232391
Status Public on Mar 27, 2024
Title Cell-mediated cytotoxicity surrounding the brain in spinal muscular atrophy
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We here longitudinally investigated how SMA and nusinersen shaped local immune responses in the cerebrospinal fluid (CSF) using single cell RNA-sequencing and single cell TCR-sequencing.
 
Overall design Single-cell RNA and TCR sequencing data of 23 individual CSF cell samples from 7 individual SMA patients that were longitudinally (baseline: n = 7; 2 months: n = 2; 6 months: n = 6; 10 months: n = 6) and 2 additional SMA patients at 10 months post_treatment.
Web link https://www.nature.com/articles/s41467-024-48195-3
 
Contributor(s) Lu I, Heming M, Meyer zu Hörste G
Citation(s) 38750052
Submission date May 12, 2023
Last update date May 20, 2024
Contact name I-Na Lu
E-mail(s) luina0416@gmail.com
Organization name University Hospital Muenster
Department Department of Neurology with Institute of Translational Neurology
Lab Neuroimmunology
Street address Mendelstr. 7
City Muenster
State/province NRW
ZIP/Postal code 48149
Country Germany
 
Platforms (3)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
GPL30173 NextSeq 2000 (Homo sapiens)
Samples (47)
GSM7329816 single_cell RNA seq data of CSF from patient SMA1_1_untreated
GSM7329817 single_cell RNA seq data of CSF from patient SMA1_1_nusinersen_6 months
GSM7329818 single_cell RNA seq data of CSF from patient SMA1_1_nusinersen_10 months
Relations
BioProject PRJNA971910

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE232391_RAW.tar 199.0 Mb (http)(custom) TAR (of CSV, H5)
GSE232391_meta.csv.gz 538.8 Kb (ftp)(http) CSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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