|
| Status |
Public on Sep 11, 2023 |
| Title |
Analysis of gene expression changes in K562 erythroleukemia cells after erythroid differentiation caused by incubation in the presence hemin [RNA-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Expression of the clusters of rDNA genes influences pluripotency, but the underlying mechanisms are not known yet. The clusters shape inter-chromosomal contacts with numerous genes controlling differentiation in human cells. The fact suggests the possible role of these contacts in formation of 3D chromosomal structures and regulation of gene expression in development. We used human leukemia K562 cells induction to erythroid differentiation in order to study the changes in gene expression.
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| |
|
| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for K562 cells untreated and incubated for 108h with 50 μM concentration of hemin.
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| |
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| Contributor(s) |
Tchurikov NA, Kravatsky YV |
| Citation(s) |
37372991, 38928039 |
| |
| Submission date |
May 12, 2023 |
| Last update date |
Jul 31, 2024 |
| Contact name |
Nickolai Tchurikov |
| E-mail(s) |
tchurikov@eimb.ru
|
| Organization name |
Engelhardt Institute of Molecular Biology
|
| Department |
Department of Epigenetic Mechanisms of Gene Expression Regulation
|
| Street address |
32, Vavilova str.
|
| City |
Moscow |
| ZIP/Postal code |
119991 |
| Country |
Russia |
| |
|
| Platforms (1) |
| GPL18460 |
Illumina HiSeq 1500 (Homo sapiens) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE232393 |
K562 erythroleukemia cells after erythroid differentiation caused by incubation in the presence of hemin |
|
| Relations |
| BioProject |
PRJNA971911 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE232390_K562.RED.FPKM.txt.gz |
592.5 Kb |
(ftp)(http) |
TXT |
| GSE232390_K562.RED.TPM.txt.gz |
599.9 Kb |
(ftp)(http) |
TXT |
| GSE232390_K562.WHITE.FPKM.txt.gz |
595.3 Kb |
(ftp)(http) |
TXT |
| GSE232390_K562.WHITE.TPM.txt.gz |
603.1 Kb |
(ftp)(http) |
TXT |
| GSE232390_RAW.tar |
13.7 Mb |
(http)(custom) |
TAR (of RESULTS) |
| GSE232390_RNAseq.RED.forward.bw |
41.9 Mb |
(ftp)(http) |
BW |
| GSE232390_RNAseq.RED.reverse.bw |
41.9 Mb |
(ftp)(http) |
BW |
| GSE232390_RNAseq.WHITE.forward.bw |
42.2 Mb |
(ftp)(http) |
BW |
| GSE232390_RNAseq.WHITE.reverse.bw |
42.3 Mb |
(ftp)(http) |
BW |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
| Processed data provided as supplementary file |
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