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Status |
Public on May 17, 2024 |
Title |
Loss of RUNX1 favors mesenchymal stem cells development at the expense of hematopoiesis in hPSC-derived hematopoiesis |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Our data demonstrated an unprecedented role of RUNX1 in regulating hematopoietic and mesenchymal fate decisions in human pluripotent stem cells (hPSC)-derived hematopoiesis
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Overall design |
We designed an alternative fluorescent gene tdTomato (tdT) and venus reporter and targeted into the non-coding region of exon 3 of RUNX1 gene, which is adjacent to the proximal promoter of RUNX1 gene, using TALEN-mediated homologous recombination
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Contributor(s) |
Wang C, Samokhvalov IM |
Citation missing |
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Submission date |
May 10, 2023 |
Last update date |
May 17, 2024 |
Contact name |
Cuihua Wang |
E-mail(s) |
wang_cuihua@gzlab.ac.cn
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Organization name |
Guangzhou Lab
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Street address |
601 Huangpu Ave, Guangzhou
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City |
Guangzhou |
State/province |
Guangdong |
ZIP/Postal code |
510632 |
Country |
China |
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Platforms (1) |
GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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Samples (36)
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Relations |
BioProject |
PRJNA971128 |