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| Status |
Public on May 08, 2023 |
| Title |
Effect of ATRX deficiency on gene expression of RCAS-nTva derived murine gliomas [RNA-seq: ATRX_Immuno_Tumor] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the impact of ATRX loss on tumor microenvironment we generated ATRX-intact and -deficient tumors in immune competent mice with the RCA-nTva system. Mice were injected with a tumorigenic RCAS construct (PDGFa and shTP53) and an RCAS bearing CRE recombinase. This was performed in mice that were ATRX wt and ATRX floxed.
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| Overall design |
We performed expression profiling using bulk RNA-sequencing of 3 tumors in each group.
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| Contributor(s) |
Whtifield B, Malgulwar P, Irvin D, Huse J |
| Citation(s) |
38272925 |
| |
| Submission date |
May 06, 2023 |
| Last update date |
Feb 09, 2024 |
| Contact name |
Benjamin Whitfield |
| E-mail(s) |
BTWhitfield@mdanderson.org
|
| Phone |
9198023476
|
| Organization name |
MD Anderson/UT Health GSBS
|
| Street address |
5918 Belrose Dr
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77035 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE231832 |
Effect of ATRX deficiency on gene expression of RCAS-nTva derived murine gliomas |
|
| Relations |
| BioProject |
PRJNA967996 |
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