Comparison of gene expression by Nanostring of activated and non activated CAR T cells expressing a CD19 CAR in the absence or presence of the dSHP2 module
Overall design
T cells from six individual donors were transduced to express an anti-CD19 CAR alone or alongside the dSHP2 module. CAR T cells were then stimulated through the CD19 CAR or left unstimulated and gene expression assessed 24hours later
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