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| Status |
Public on Aug 07, 2023 |
| Title |
Pyruvate dehydrogenase complex integrates the metabolome and epigenome in memory T cell differentiation in vitro [ATAC-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
The chromatin landscape was assessed in effector and memory T-cells obtained from wildtype and pyruvate dehydrogenase knockout mouse. Disruption of the metabolic processes involving pyruvate dehydrogenase can affect T-cell differentiation through epigenetic and metabolic mechanisms.
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| |
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| Overall design |
Comparison of chromatin structure between wildtype and TPdh-/- (pyruvate dehydrogenase knockout) mice using ATAC-seq data
contributor: NISC Comparative Sequencing Program
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| |
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| Contributor(s) |
Tarasenko TN, Banerjee P, Gomez-Rodriguez J, Gildea DE, Zhang S, Wolfsberg TG, Jenkins L, McGuire PJ |
| Citation(s) |
37215014 |
| |
| Submission date |
May 03, 2023 |
| Last update date |
Aug 08, 2023 |
| Contact name |
Peter McGuire |
| E-mail(s) |
peter.mcguire@nih.gov, payal.banerjee@nih.gov
|
| Organization name |
NHGRI
|
| Street address |
10 Center Dr
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE231556 |
Pyruvate dehydrogenase complex integrates the metabolome and epigenome in memory CD8+ T cell differentiation in vitro |
|
| Relations |
| BioProject |
PRJNA966912 |
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