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Series GSE231351 Query DataSets for GSE231351
Status Public on May 13, 2023
Title Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary This study shows in a polyclonal setting that routine exposure to food protein promotes accumulation of antigen-experienced CD4+ T cells in the intestinal epithelium, which acquire a cytotoxic tissue-resident transcriptional program. This process is disrupted upon either allergic sensitization or tolerance.
Overall design Single CD4+ T cells from the small intestine epithelium or lamina propria of mice with different dietary and microbial manipulations; libraries are the antibody derived tags, gene expression and tcr sequencing.
Contributor(s) Lockhart A, Reed A, Castro TB, Herman C, Canesso MC, Mucida D
Citation(s) 37191720
Submission date Apr 30, 2023
Last update date Aug 08, 2023
Contact name Tiago Castro
Organization name The Rockefeller University
Lab Laboratory of Mucosal Immunology
Street address 1230 York Avenue
City New York
State/province New York
ZIP/Postal code 10065
Country USA
Platforms (2)
GPL19057 Illumina NextSeq 500 (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (15)
GSM7265577 Small intestine CD4 from GF mice fed AA or OVA diet - Hashtags
GSM7265578 Small intestine CD4 from GF mice fed AA or OVA diet - Gex
GSM7265579 Small intestine CD4 from GF mice fed AA or OVA diet - TCR
BioProject PRJNA964460

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Supplementary file Size Download File type/resource
GSE231351_RAW.tar 1.2 Gb (http)(custom) TAR (of CSV, MTX, RDS, TSV)
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Raw data are available in SRA
Processed data provided as supplementary file

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