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Series GSE23065 Query DataSets for GSE23065
Status Public on Aug 30, 2010
Title Multiple chromosomal monosomies are characteristic of giant cell ependymoma
Organism Homo sapiens
Experiment type Genome variation profiling by genome tiling array
Summary Giant cell ependymoma (GCE), a rare ependymoma subtype, was only recently recognised as a separate diagnostic entity with variations both in malignant potential and in course of disease. The pathogenetic mechanisms behind ependymomas remain unknown. Only one karyotyped GCE has so far been reported. We present the first genomic characterisation of a supratentorial GCE using G-band karyotyping, DNA ploidy analysis and array comparative genomic hybridisation (aCGH). The G-banded karyotype was hypodiploid with multiple monosomies, a feature present also in the previously published case and, hence, probably characteristic of these tumours. We could also analyse cytogenetically a subsequent recurrent tumour, phenotypically an anaplastic ependymoma, but exhibiting a pattern of monosomies largely similar to that found in the primary tumour, allowing a first insight into the genetic events involved also in disease progression.
Overall design 2 tumour samples analysed with the control DNA (supplied by Agilent)
Contributor(s) Dahlback HS, Brandal P, Krossnes BK, Fric R, Meling TR, Meza-Zepeda LA, Danielsen HE, Heim S
Citation(s) 21683982
Submission date Jul 21, 2010
Last update date Dec 06, 2012
Contact name Hanne-Sofie S Dahlback
Organization name The Norwegian Radium Hospital
Department Section for Cancer Cytogenetics
Street address Montebello
City Oslo
ZIP/Postal code 0310
Country Norway
Platforms (1)
GPL10123 Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version)
Samples (2)
GSM568877 Tumor_initial
GSM568878 Tumor_recurrence
BioProject PRJNA129873

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23065_RAW.tar 99.9 Mb (http)(custom) TAR (of TXT, XLS)
Processed data included within Sample table
Processed data provided as supplementary file

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