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Series GSE230240 Query DataSets for GSE230240
Status Public on Sep 13, 2023
Title Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia gene intraflagellar transport homolog 88 in Alzheimer's disease
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary This study identified the specific types of hippocampal neurons whose axons are vulnerable to amyloid-β accumulation. We used the inDropsTM platform to sequence 8 libraries: 5 libraries from the hippocampus of Alzheimer’s disease mice at 12,20, and, 24 weeks of age, and 3 libraries from the hippocampus of normal age-matched mice for the purpose of finding the selectively vulnerable hippocampal neuron type. 22,233 cells with 72,146 transcriptomes were collected after quality control was completed. When the 5,468 neurons that were marked by the expression of Snap25, Syt1, Ndrg4, and Meg3 were examined, we found that three types of neurons, such as somatostatin, chromogranin B, and calbindin-expressing neurons in the hippocampus, were selectively vulnerable to amyloid-β overexpression.
 
Overall design We used the inDropsTM platform to sequence 8 libraries: 5 libraries from the hippocampus of Alzheimer’s disease mice at 12,20, and, 24 weeks of age, and 3 libraries from the hippocampus of normal age-matched mice for the purpose of finding the selectively vulnerable hippocampal neuron type.
 
Contributor(s) Jang J, Yeo S, Jung H, Lee M, Ba S, Choe Y
Citation(s) 37667395, 37942288
Submission date Apr 21, 2023
Last update date Dec 01, 2023
Contact name Jaemyung Jang
Organization name Korea Brain Research Institute
Street address 61, Cheomdan-ro, Dong-gu
City Daegu
ZIP/Postal code 41062
Country South Korea
 
Platforms (2)
GPL19057 Illumina NextSeq 500 (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (8)
GSM7208889 WT, ctrl 1, scRNAseq
GSM7208890 WT, ctrl 2, scRNAseq
GSM7208891 WT, ctrl 3, scRNAseq
Relations
BioProject PRJNA958109

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Supplementary file Size Download File type/resource
GSE230240_RAW.tar 60.6 Mb (http)(custom) TAR (of CSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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