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Series GSE229710 Query DataSets for GSE229710
Status Public on May 15, 2023
Title Effect of Interferon Gamma and Hydroxyproline on Gene Expression in THP-1 Cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Hydroxyproline (trans-4-Hydroxy-L-proline) is an abundant amino acid in mammalian tissue, yet little is known about how its prescence effects gene expression. This study aimed to analyze the effects of hydroxyproline on gene expression in THP-1 cells stimulated with IFN-γ, using RNA-seq.
Overall design RNA-seq analysis was perfromed on samples from THP-1 cells treated for 72 hours with a vehicle control alone, vehicle and IFN-γ (50 ng/ml), or hydroxyproline (40 mM) and IFN-γ were compared. Three replicates per condition were included. Differential gene expression analysis was performed.
Contributor(s) Spangenberg SH, Palermo A, Lairson LL, Siuzdak G
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Submission date Apr 14, 2023
Last update date May 15, 2023
Contact name Stephan Spangenberg
Phone 9253255007
Organization name The Scripps Research Institute
Department Chemistry
Lab Lairson
Street address 10550 N Torrey Pines Rd, La Jolla, CA 92037
State/province CA
ZIP/Postal code 92121
Country USA
Platforms (1)
GPL30173 NextSeq 2000 (Homo sapiens)
Samples (9)
GSM7173739 THP1_vehicle_1
GSM7173740 THP1_vehicle_2
GSM7173741 THP1_vehicle_3
BioProject PRJNA955675

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Supplementary file Size Download File type/resource
GSE229710_merged_tpm.txt.gz 1.3 Mb (ftp)(http) TXT
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