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Series GSE22956 Query DataSets for GSE22956
Status Public on Dec 31, 2010
Title NFAT5 is a critical regulator of rheumatoid inflammation
Organism Homo sapiens
Experiment type Expression profiling by array
Summary NFAT5 is an osmoprotective transcription factor whose DNA binding domain shares structural homology with NFkappaB and other member of NFAT family, but its role in chronic inflammatory diseases remains unclear. The mRNA profiling of synoviocytes and endothelial cells transfected with NFAT5-targeted siRNA reveals three major changes in cellular processes associated with the pathogenesis of rheumatoid arthritis: cell cycle and survival, angiogenesis, and cell migration.
 
Overall design The cells were transfected with NFAT5-targeted siRNA or non-specific scrambled (control) siRNA.
 
Contributor(s) Kim W, Hwang D, Cho C
Citation(s) 21717420
Submission date Jul 15, 2010
Last update date Aug 16, 2018
Contact name Sungyong You
E-mail(s) Sungyong.You@cshs.org
Organization name Cedars-Sinai Medical Center
Department Surgery
Lab Freeman Lab.
Street address Beverly Blvd 8400
City LA
State/province CA
ZIP/Postal code 90048
Country USA
 
Platforms (2)
GPL6883 Illumina HumanRef-8 v3.0 expression beadchip
GPL6947 Illumina HumanHT-12 V3.0 expression beadchip
Samples (21)
GSM566718 Non-transfected RA-FLS biological replicate 1
GSM566719 Control siRNA transfected RA-FLS biological replicate 1
GSM566720 NFAT5 siRNA transfected RA-FLS biological replicate 1
Relations
BioProject PRJNA127927

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE22956_GPL6883_non-normalized.txt.gz 1.3 Mb (ftp)(http) TXT
GSE22956_GPL6947_non-normalized.txt.gz 3.3 Mb (ftp)(http) TXT
GSE22956_RAW.tar 10.2 Mb (http)(custom) TAR
Processed data included within Sample table

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