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| Status |
Public on Mar 18, 2011 |
| Title |
Genome-wide analysis of time-dependent gene expression in SUM-225 cells treated with the HER-2-specific inhibitor CP724,714 for 45 hours |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Results of blocking the HER-2 oncogene kinase function in SUM-225 cells by treatment with CP724,714 and measuring gene expression as a function of time provides information as to what genes are regulated by HER-2 in this breast cancer cell line.
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| |
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| Overall design |
SUM-225 cells were treated with the HER-2-specific small molecule kinase inhibitor CP724,714 for 45 hours. Total RNA was collected every 3 hours from parallel cultures throughout the 45 hour duration of treatment and genome-wide analysis of expression was performed on RNA from each time point (total 16 time points, starting at 0 hours treatment).
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| |
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| Contributor(s) |
Bollig-Fischer A, Ethier SP |
| Citation(s) |
21437235, 25028721 |
| Submission date |
Jul 15, 2010 |
| Last update date |
Mar 20, 2017 |
| Contact name |
Aliccia B Bollig-Fischer |
| E-mail(s) |
bollig@karmanos.org
|
| Organization name |
Karmanos Cancer Inst., Wayne State University
|
| Street address |
4100 John R, HWCRC rm 815
|
| City |
Detroit |
| State/province |
MI |
| ZIP/Postal code |
48201 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6883 |
Illumina HumanRef-8 v3.0 expression beadchip |
|
| Samples (16)
|
| GSM566687 |
CP724,714-treated_9hour |
| GSM566688 |
CP724,714-treated_12hour |
| GSM566689 |
CP724,714-treated_15hour |
| GSM566690 |
CP724,714-treated_18hour |
| GSM566691 |
CP724,714-treated_21hour |
| GSM566692 |
CP724,714-treated_24hour |
| GSM566693 |
CP724,714-treated_27hour |
| GSM566694 |
CP724,714-treated_30hour |
| GSM566695 |
CP724,714-treated_33hour |
| GSM566696 |
CP724,714-treated_36hour |
| GSM566697 |
CP724,714-treated_39hour |
| GSM566698 |
CP724,714-treated_42hour |
| GSM566699 |
CP724,714-treated_45hour |
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| This SubSeries is part of SuperSeries: |
| GSE23176 |
Oncogene activation induces metabolic transformation resulting in insulin independence in human breast cancer cells |
|
| Relations |
| BioProject |
PRJNA133093 |
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