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Series GSE229266 Query DataSets for GSE229266
Status Public on Apr 10, 2023
Title Sex-Specific Effects of Early-Life Iron Deficiency and Prenatal Choline Treatment on Adult Rat Hippocampal Transcriptome
Organism Rattus norvegicus
Experiment type Expression profiling by high throughput sequencing
Summary Fetal-neonatal iron deficiency (ID) causes long-term and sex specific neurocognitive and affective dysfunctions. This study aims to illustrate sex- specific transcriptome alterations in adult rat hippocampus induced by fetal-neonatal ID and prenatal choline treatment.
Overall design Hippocampi were collected from 16 female rats at postnatal day 65 (P65) and analyzed for changes in gene expression. Rats were fed one of the following diets: iron suficient (IS), iron suficient with choline supplementation (ISch), iron deficient (ID) or iron deficient with choline supplementation (IDch). There were 4 biological replicates per treatment. The same experimental design was applied separatedly to 16 male rats.
Contributor(s) Liu SX, Fredrickson TK, Calixto Mancipe N, Georgieff MK, Tran PV
Citation(s) 36986048
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 NS099178 Roles of Iron-Dependent PHD and JARID in Early-Life Iron Deficiency-Induced Adult Neural Gene Dysregulation UNIVERSITY OF MINNESOTA PHU V. TRAN
R01 HD029421 Newborn Iron Deficiency UNIVERSITY OF MINNESOTA Michael K. Georgieff
Submission date Apr 09, 2023
Last update date Apr 17, 2023
Contact name Phu V Tran
Phone 6126267964
Organization name University of Minnesota
Department Department of Pediatrics
Lab PWB 13-231
Street address 516 Delaware St., SE
City Minneapolis
State/province MN
ZIP/Postal code 55455
Country USA
Platforms (2)
GPL14844 Illumina HiSeq 2000 (Rattus norvegicus)
GPL25947 Illumina NovaSeq 6000 (Rattus norvegicus)
Samples (32)
GSM7157783 male, iron sufficient, rep1
GSM7157784 male, iron sufficient, rep2
GSM7157785 male, iron sufficient, rep3
BioProject PRJNA953771

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE229266_p65female_raw.txt.gz 748.8 Kb (ftp)(http) TXT
GSE229266_p65male_raw.txt.gz 690.7 Kb (ftp)(http) TXT
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