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Series GSE228569 Query DataSets for GSE228569
Status Public on Apr 28, 2023
Title CIRCLE-seq analyais for -175 site
Organism Homo sapiens
Experiment type Other
Summary Adenosine base editing to recreate the HPFH mutations is a promising approach to induce HbF. We used CIRCLE-seq to identify 682 potential off-target sites in purified DNA treated with Cas9 nuclease complexed to sgRNA targeting -globin -175 .
Overall design CIRCLE-seq was performed in HEK293T cells.
Contributor(s) Mayuranathan T, Yen J
Citation(s) 37400614
Submission date Mar 30, 2023
Last update date Jan 02, 2024
Contact name Jonanthan Yen
Organization name St. Jude Children's Research Hospital
Department Hematology
Street address 262 Danny Thomas Pl
City Memphis
State/province TN
ZIP/Postal code 38105
Country USA
Platforms (1)
GPL15520 Illumina MiSeq (Homo sapiens)
Samples (1)
GSM7124235 175_S1
This SubSeries is part of SuperSeries:
GSE228822 Potent and uniform fetal hemoglobin induction via base editing
BioProject PRJNA951689

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE228569_RAW.tar 130.0 Kb (http)(custom) TAR (of TAR, TXT, YAML)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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