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Status |
Public on May 31, 2023 |
Title |
Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
Helminth infection leads to lung remodelling. We used single cell ATAC sequencing (scRNA-seq) to analyze the changes in lung cells following exposure to N. brasiliensis at day 28 and day 45 post helminth infection
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Overall design |
Single cell suspension of lungs cells was obtained from pooled samples from controls and helminth exposed mice. CD45+ immune cells were enriched in the pooled samples
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Web link |
http://10.1126/sciimmunol.adf8161
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Contributor(s) |
Oyesola O, Zhao M, Loke P |
Citation(s) |
37566678 |
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Submission date |
Mar 29, 2023 |
Last update date |
Aug 30, 2023 |
Contact name |
Oyebola Oyesola |
E-mail(s) |
oyebola.oyesola@nih.gov
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Phone |
607-379-7745
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Organization name |
National Institute of Health
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Department |
Type 2 Immunity Section
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Lab |
LPD
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Street address |
Building 4, Room B1 05 4 Memorial Drive Bethesda, MD 20892
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City |
Maryland |
ZIP/Postal code |
20852 |
Country |
USA |
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Platforms (1) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (3) |
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This SubSeries is part of SuperSeries: |
GSE228507 |
Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation |
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Relations |
BioProject |
PRJNA950194 |