|
| Status |
Public on May 31, 2023 |
| Title |
Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Helminth infection leads to lung remodelling. We used single cell ATAC sequencing (scRNA-seq) to analyze the changes in lung cells following exposure to N. brasiliensis at day 28 and day 45 post helminth infection
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| |
|
| Overall design |
Single cell suspension of lungs cells was obtained from pooled samples from controls and helminth exposed mice. CD45+ immune cells were enriched in the pooled samples
|
| Web link |
http://10.1126/sciimmunol.adf8161
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| |
|
| Contributor(s) |
Oyesola O, Zhao M, Loke P |
| Citation(s) |
37566678 |
| |
| Submission date |
Mar 29, 2023 |
| Last update date |
Aug 30, 2023 |
| Contact name |
Oyebola Oyesola |
| E-mail(s) |
oyebola.oyesola@nih.gov
|
| Phone |
607-379-7745
|
| Organization name |
National Institute of Health
|
| Department |
Type 2 Immunity Section
|
| Lab |
LPD
|
| Street address |
Building 4, Room B1 05 4 Memorial Drive Bethesda, MD 20892
|
| City |
Maryland |
| ZIP/Postal code |
20852 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (3) |
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| This SubSeries is part of SuperSeries: |
| GSE228507 |
Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation |
|
| Relations |
| BioProject |
PRJNA950194 |
