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Series GSE228219 Query DataSets for GSE228219
Status Public on Jan 01, 2024
Title Differential gene expression in beta cells and non-beta cells from islets of NOD mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Diabetes (T1D) is a disease in which the immune system destroys the insulin-producing beta cells. Recently, researchers have become interested in the role of the innate immune system in initiating this process. To further investigate this, we used RNA-seq to analyze sorted beta cells from non-diabetic and pre-diabetic female non-obese models of diabetes (NOD). These results shed light on the potential involvement of m6A mediators in the development of T1D, highlighting a promising avenue for future research.
Overall design RNA-seq was performed on FACS sorted islet cells by autofluorescence beta and non-beta cells from NOD female mice.
Contributor(s) DeJesus D, Kulkarni R
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Submission date Mar 26, 2023
Last update date Jan 01, 2024
Contact name Hui Pan
Organization name Joslin Diabetes Center
Department Bioinformatics and Biostatistics Core
Street address 1 Joslin Place
City Boston
ZIP/Postal code 02215
Country USA
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (12)
GSM7117049 1 Beta_Week4
GSM7117050 2 Beta_Week4
GSM7117051 3 Beta_Week4
BioProject PRJNA948841

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE228219_count_table.csv.gz 1.3 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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