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| Status |
Public on Sep 13, 2023 |
| Title |
Exosomal circEZH2_005, an intestinal injury biomarker, alleviates intestinal ischemia/reperfusion injury by mediating hnRNPA1/Gprc5a signaling |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
Although plasma exosomal circular RNAs (circRNAs) are valuable biomarkers and therapeutic targets for various diseases, their role in intestinal I/R injury remains unknown. This study screens the expression profile of circRNAs in intestinal tissue exosomes collected from intestinal I/R mice.
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| Overall design |
We performed high-throughput sequencing of circRNA to characterize differential expression profiles of circRNA in intestinal tissue exosomes after I/R injury from four mice with intestinal I/R (1 h of ischemia and 2 h of reperfusion) and sham.
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| Contributor(s) |
Zhang W, Zhou B, Yang X, Li C, Liu K |
| Citation(s) |
37673874 |
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| Submission date |
Mar 14, 2023 |
| Last update date |
Sep 13, 2023 |
| Contact name |
Wen-Juan Zhang |
| E-mail(s) |
zhangwj319@126.com
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| Phone |
15626220261
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| Organization name |
Nanfang Hospital, Southern Medical University
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| Street address |
Guangzhou, 1838 Guangzhou Avenue North, Guangzhou 510515, China
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| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510515 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (8)
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| GSM7098842 |
intestinal tissue exosomes, I1(ischemia 1h/reperfusion 2h), rep1 |
| GSM7098843 |
intestinal tissue exosomes,I2(ischemia 1h/reperfusion 2h), rep2 |
| GSM7098844 |
intestinal tissue exosomes,I4(ischemia 1h/reperfusion 2h), rep3 |
| GSM7098845 |
intestinal tissue exosomes,I5(ischemia 1h/reperfusion 2h), rep4 |
| GSM7098846 |
intestinal tissue exosomes,S2(sham),rep1 |
| GSM7098847 |
intestinal tissue exosomes,S3(sham),rep2 |
| GSM7098848 |
intestinal tissue exosomes,S4(sham),rep3 |
| GSM7098849 |
intestinal tissue exosomes,S5(sham),rep4 |
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| Relations |
| BioProject |
PRJNA944694 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE227355_TMM_normalized_CPM.xlsx |
14.3 Kb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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