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Series GSE227176 Query DataSets for GSE227176
Status Public on Sep 11, 2023
Title Mechanisms of endothelial injury and transplant-associated thrombotic microangiopathy in tandem autologous hematopoietic stem cell transplant for neuroblastoma
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Our data indicate that endothelial injury is increased in auto-stem cell transplant patients receiving the specific conditioning regimen carboplatin, etoposide and melphalan and is associated with clinical TA-TMA. Moreover, our data identify specific pathways that can be targeted to treat or prevent TA-TMA.
 
Overall design RNAseq was performed on glomerular endothelial cells cultured with serum from neuroblastoma patients who developed TA-TMA (n=5), timepoint-matched serum from neuroblastoma patients who did not develop TA-TMA (n=4) and complete media alone (no human serum, n=1).
 
Contributor(s) Sabulski A, Abdullah S, Luebbering N, Aunins B, Jodele S, Davies SM
Citation(s) 37317894
Submission date Mar 12, 2023
Last update date Dec 12, 2023
Contact name Stella Davies
E-mail(s) Stella.Davies@cchmc.org
Organization name Cincinnati Children's Hospital
Department Cancer & Blood Disease Institute
Lab Davies
Street address 3333 Burnet Ave
City Cincinnati
State/province OH
ZIP/Postal code 45229
Country USA
 
Platforms (1)
GPL30173 NextSeq 2000 (Homo sapiens)
Samples (18)
GSM7092747 No TA-TMA control [TSSA1]
GSM7092748 No TA-TMA control [TSSA2]
GSM7092749 No TA-TMA control [TSSA3]
Relations
BioProject PRJNA943507

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE227176_controlTSSA11121314_vs_comparisonTSSA1617181920.genes.deseq.counts.csv.gz 1.3 Mb (ftp)(http) CSV
GSE227176_controlTSSA1234_vs_comparisonTSSA678910.genes.deseq.counts.csv.gz 1.3 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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