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Status |
Public on Dec 01, 2023 |
Title |
Distinct gene expression signatures comparing latent tuberculosis infection with different routes of Bacillus Calmette-Guérin vaccination |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
RNA-Seq was utilized to provide an unbiased assessment of systemic and mucosal immunity using blood cells from LTBI subjects and recipients of ID and oral (PO) BCG.
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Overall design |
BAL cell gene expression was evaluated after overnight culture in medium alone (baseline conditions), or with virulent Mtb strain H37Rv in patients with latent tuberculosis infection (LTBI) and in BCG-vaccinated (ID and PO groups) and Mtb/BCG-naive patients.
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Contributor(s) |
Silver R, Hoft D, Storer C, Head R |
Citation(s) |
38129388 |
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Submission date |
Jan 29, 2023 |
Last update date |
Jan 02, 2024 |
Contact name |
Richard Silver |
E-mail(s) |
rfs4@case.edu
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Organization name |
Case Western Reserve University and the Louis Stokes Cleveland VA Medical Center
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Department |
Division of Pulmonary, Critical Care and Sleep Medicine
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Street address |
10900 Euclid Ave
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City |
Cleveland |
State/province |
OH |
ZIP/Postal code |
44106 |
Country |
USA |
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Platforms (1) |
GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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Samples (54)
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GSM7009632 |
patient N171, uninfected_in_vitro, control_group |
GSM7009633 |
patient P060, uninfected_in_vitro, ltbi_group |
GSM7009634 |
patient P061, uninfected_in_vitro, ltbi_group |
GSM7009635 |
patient P080, uninfected_in_vitro, ltbi_group |
GSM7009636 |
patient N173, uninfected_in_vitro, control_group |
GSM7009637 |
patient P077, uninfected_in_vitro, ltbi_group |
GSM7009638 |
patient P054, uninfected_in_vitro, ltbi_group |
GSM7009639 |
patient N175, uninfected_in_vitro, control_group |
GSM7009640 |
patient N162, uninfected_in_vitro, control_group |
GSM7009641 |
patient P079, uninfected_in_vitro, ltbi_group |
GSM7009642 |
patient N091, uninfected_in_vitro, control_group |
GSM7009643 |
patient 02BAL001, uninfected_in_vitro, id_group |
GSM7009644 |
patient 02BAL018, uninfected_in_vitro, id_group |
GSM7009645 |
patient 02BAL017, uninfected_in_vitro, po_group |
GSM7009646 |
patient 02BAL016, uninfected_in_vitro, id_group |
GSM7009647 |
patient 02BAL015, uninfected_in_vitro, id_group |
GSM7009648 |
patient 02BAL014, uninfected_in_vitro, id_group |
GSM7009649 |
patient 02BAL013, uninfected_in_vitro, id_group |
GSM7009650 |
patient 02BAL012, uninfected_in_vitro, id_po_group |
GSM7009651 |
patient 02BAL011, uninfected_in_vitro, po_group |
GSM7009652 |
patient 02BAL010, uninfected_in_vitro, id_group |
GSM7009653 |
patient 02BAL009, uninfected_in_vitro, id_po_group |
GSM7009654 |
patient 02BAL008, uninfected_in_vitro, id_group |
GSM7009655 |
patient 02BAL007, uninfected_in_vitro, po_group |
GSM7009656 |
patient 02BAL005, uninfected_in_vitro, po_group |
GSM7009657 |
patient 02BAL006, uninfected_in_vitro, po_group |
GSM7009658 |
patient 02BAL004, uninfected_in_vitro, po_group |
GSM7009659 |
patient N171, mtb_infected_in_vitro, control_group |
GSM7009660 |
patient P060, mtb_infected_in_vitro, ltbi_group |
GSM7009661 |
patient P061, mtb_infected_in_vitro, ltbi_group |
GSM7009662 |
patient P080, mtb_infected_in_vitro, ltbi_group |
GSM7009663 |
patient N173, mtb_infected_in_vitro, control_group |
GSM7009664 |
patient P077, mtb_infected_in_vitro, ltbi_group |
GSM7009665 |
patient P054, mtb_infected_in_vitro, ltbi_group |
GSM7009666 |
patient N175, mtb_infected_in_vitro, control_group |
GSM7009667 |
patient N162, mtb_infected_in_vitro, control_group |
GSM7009668 |
patient P079, mtb_infected_in_vitro, ltbi_group |
GSM7009669 |
patient N091, mtb_infected_in_vitro, control_group |
GSM7009670 |
patient 02BAL001, mtb_infected_in_vitro, id_group |
GSM7009671 |
patient 02BAL018, mtb_infected_in_vitro, id_group |
GSM7009672 |
patient 02BAL017, mtb_infected_in_vitro, po_group |
GSM7009673 |
patient 02BAL016, mtb_infected_in_vitro, id_group |
GSM7009674 |
patient 02BAL015, mtb_infected_in_vitro, id_group |
GSM7009675 |
patient 02BAL014, mtb_infected_in_vitro, id_group |
GSM7009676 |
patient 02BAL013, mtb_infected_in_vitro, id_group |
GSM7009677 |
patient 02BAL012, mtb_infected_in_vitro, id_po_group |
GSM7009678 |
patient 02BAL011, mtb_infected_in_vitro, po_group |
GSM7009679 |
patient 02BAL010, mtb_infected_in_vitro, id_group |
GSM7009680 |
patient 02BAL009, mtb_infected_in_vitro, id_po_group |
GSM7009681 |
patient 02BAL008, mtb_infected_in_vitro, id_group |
GSM7009682 |
patient 02BAL007, mtb_infected_in_vitro, po_group |
GSM7009683 |
patient 02BAL005, mtb_infected_in_vitro, po_group |
GSM7009684 |
patient 02BAL006, mtb_infected_in_vitro, po_group |
GSM7009685 |
patient 02BAL004, mtb_infected_in_vitro, po_group |
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Relations |
BioProject |
PRJNA929281 |
Supplementary file |
Size |
Download |
File type/resource |
GSE223999_BAL_all.gene_CPM.txt.gz |
8.8 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
Raw data are available in SRA |
Processed data are available on Series record |
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