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Series GSE223833 Query DataSets for GSE223833
Status Public on Jun 01, 2023
Title Recruitment of stem-like T cells and resistance to exhaustion support CD4 T cell responses in autoimmunity (scCITE-Seq).
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Recent findings suggest that undifferentiated, stem-like, antigen specific T cells serve as an important long-term reservoir for autoimmune CD8 T cell responses. However, it is still unclear whether CD4 T cells exhibit a similar differentiation trajectory culminating in terminal differentiation, acquisition of an exhausted phenotype, and loss of stemness and function. We analyzed islet infiltrating T cells by scRNAseq and flow cytometry and found that while CD4 T cells in autoimmune diabetes share many features of exhaustion with CD8 T cells, expression patterns of inhibitory receptors are distinct in autoimmune T cells compared to T cells in chronic LCMV infection.
Overall design scCITE-Seq
Contributor(s) Allard D, Raugh A, Perkins B, Aljobaily N, Kolawole E, Liu B, Galland T, Jing Y, Stephens Z, Evavold B, Hale S, Bettini ML, Bettini M
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Submission date Jan 26, 2023
Last update date Jun 03, 2023
Contact name Maria Bettini
Organization name University of Utah
Street address University of Utah
City Salt Lake City
ZIP/Postal code 84112
Country USA
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (12)
GSM6997587 Pancreatic islets T cells, mRNA-derived cDNA, biol rep1
GSM6997588 Pancreatic islets T cells, mRNA-derived cDNA, biol rep2
GSM6997589 Pancreatic islets T cells, mRNA-derived cDNA, biol rep3
BioProject PRJNA928482

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Supplementary file Size Download File type/resource
GSE223833_RAW.tar 171.7 Mb (http)(custom) TAR (of CSV, MTX, TSV)
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Raw data are available in SRA
Processed data provided as supplementary file

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