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| Status |
Public on Jun 22, 2024 |
| Title |
Transcriptomic evidence of lung repair in paediatric ARDS survival |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Pediatric patients survive from acute respiratory distress syndrome (ARDS) better than adults. However, immunological characteristics of lung tissue and peripheral circulation in pediatric ARDS has been scared. A 10-year-old girl suffered from ARDS was treated with anti-infection, anti-inflammatory regimen and with ECMO support. Air leak was fixed by surgery. Surgically dissected lung biopsies and peripheral blood cells (PBCs) were obtained from this patient and other control subjects for single cell RNA sequencing analysis. Pathological examination was also conducted on the lung biopsy. Out data revealed transcriptional characteristics of PBCs and lung microenvironment during ARDS recovery phase, and pointed out that efficient oxygen supply, appropriate immune regulation, and adequate anti-infection treatment favor for the recovery of children from ARDS.
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| Overall design |
Lung tissues and peripheral blood samples were collected for single-cell transcriptomic analyses.
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| Contributor(s) |
Song L, Li K, Hong X, Xiao K, Mo G, Zheng M, Xie F, Liu Y, Liu P, Sun T, Wang B, Feng Q, Zhou A, Yao C, Wang J, Chen H, Xie L |
| Citation(s) |
37592372 |
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| Submission date |
Jan 26, 2023 |
| Last update date |
Jun 24, 2024 |
| Contact name |
Kuan Li |
| E-mail(s) |
kuan_li@sina.cn
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| Phone |
8618630932578
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| Organization name |
Tianjin Key Laboratory of Pulmonary Regenerative Medicine
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| Street address |
Jingu road 890
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| City |
Tianjin |
| State/province |
Tianjin |
| ZIP/Postal code |
300350 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (7)
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| GSM6995422 |
Lung tissue, a 10-year girl with ARDS, scRNAseq |
| GSM6995423 |
Lung tissue, healthy control, a 1-year boy with lung sequestration, scRNAseq |
| GSM6995424 |
Lung tissue, healthy control, a 3-year boy with metastatic hepatoblastoma, scRNAseq |
| GSM6995425 |
Peripheral blood cells, a 10-year girl with ARDS at the point of ECMO initiation, scRNAseq |
| GSM6995426 |
Peripheral blood cells, a 10-year girl with ARDS at the point of ECMO weaning off, scRNAseq |
| GSM6995427 |
Peripheral blood cells, a 10-year girl with ARDS at the point of ICU check out, scRNAseq |
| GSM6995428 |
Peripheral blood cells, healthy control, a 15-year girl with heart failure before heart transplantation, scRNAseq |
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| Relations |
| BioProject |
PRJNA928385 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE223793_RAW.tar |
374.9 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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