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Series GSE22305 Query DataSets for GSE22305
Status Public on Oct 21, 2010
Title Clinical relevance of SKP2 alterations in metastatic melanoma
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by SNP array
SNP genotyping by SNP array
Summary Melanoma cell lines were genotyped to evaluate copy number differences between nodular melanoma (NM) and superficial spreading melanoma (SSM). Cell lines were also evaluated for copy number alterations in the SKP2/p27 axis.
Affymetrix SNP arrays were performed according to manufacturer's instructions using DNA extracted from 18 melanoma cell lines and 4 melanocyte controls.
Overall design Affymetrix SNP6.0 Array data for melanoma cell lines
Copy number analysis of Affymetrix SNP 6.0 arrays was performed on 18 melanoma cell lines including 2 primary superficial spreading melanoma, 2 primary nodular melanoma, 2 metastatic nodular melanoma, and 12 metastatic cell lines. Four melanocyte control lines were also evaluated including 2 immortalized melanocyte cell lines (Hermes 1 and 2B) and 2 normal melanocyte lines cultured from neonatal foreskin (HEM-N and HEM-LP) that were used to construct the baseline for copy number analysis.
Contributor(s) Osman I
Citation(s) 20883453, 21343389
Submission date Jun 11, 2010
Last update date Nov 27, 2018
Contact name Iman Osman
Phone 212-263-9089
Fax 212-263-9090
Organization name New York University School of Medicine
Department Urology
Street address 522 First Avenue, SML405
City New York
State/province NY
ZIP/Postal code 10016
Country USA
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (22)
GSM555167 Normal human melanocyte_HEM-N [SNP]
GSM555168 Normal human melanocyte_HEM-LP [SNP]
GSM555169 Immortalized melanocyte_Hermes1 [SNP]
This SubSeries is part of SuperSeries:
GSE22306 Integrative genomics identifies molecular alterations that differentiate superficial spreading and nodular melanoma
BioProject PRJNA129247

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE22305_RAW.tar 980.4 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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