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Series GSE22208 Query DataSets for GSE22208
Status Public on Oct 07, 2010
Title Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
Summary We integrate high-resolution copy number data with transcriptional profiles and identify the immunoregulatory genes, PD-L1 and PD-L2, as key targets at the 9p24.1 amplification peak in HL and MLBCL cell lines.
Overall design DNA copy number alterations were defined in DLBCL and HL cell lines, normalized to healthy donors, by GISTIC analysis of Affymetrix SNP 6.0 single nucleotide polymorphism microarray data. Using this analysis, we identified 9p24 amplification to be over-represented in HL cell lines compared to DLBCL cell lines.
Contributor(s) Green MR, Monti S, Takeyama K, Shipp MA
Citation(s) 20628145
Submission date Jun 08, 2010
Last update date Nov 27, 2018
Contact name Michael Richard Green
Phone 6175829074
Organization name Dana-Farber Cancer Institute
Department Medical Oncology
Lab Shipp Lab
Street address 44 Binney Street
City Boston
State/province MA
ZIP/Postal code 02446
Country USA
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (48)
GSM552401 DB
GSM552430 HD-LM-2
BioProject PRJNA128875

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE22208_RAW.tar 1.5 Gb (http)(custom) TAR (of CEL)
GSE22208_readme.txt 842 b (ftp)(http) TXT
GSE22208_scores.gistic.txt.gz 94.6 Kb (ftp)(http) TXT
Processed data are available on Series record

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