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Series GSE221705 Query DataSets for GSE221705
Status Public on Feb 23, 2023
Title Transcriptomic characterization of control and drug-treated APOB-mutant organoids to study steatosis-resolving drug effects
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We treated APOB-mutant organoids with different anti-NAFLD drug candidates that were effective at resolving steatosis. To understand the mechanisms of drug action and adverse drug effects we performed bulk RNA-sequencing on drug-treated and vehicle-treated APOB mutant organoids.
 
Overall design APOB-mutant organoids, 2 clonal lines from 2 different donors, were treated with the respective drug (ACCi, FASi, DGAT2i, FXRa, or hFGF19) or vehicle (control) for 7 days. Thereafter, organoids were harvested for RNA extraction.
 
Contributor(s) Delilah H, Benedetta A, Hans C
Citation(s) 36823355
Submission date Dec 23, 2022
Last update date Jun 01, 2023
Contact name Delilah Hendriks
Organization name Hubrecht Institute
Street address Uppsalalaan 8
City Utrecht
ZIP/Postal code 3584 CT
Country Netherlands
 
Platforms (1)
GPL30173 NextSeq 2000 (Homo sapiens)
Samples (12)
GSM6893374 ACCi treated APOB-/- organoids from donor 1
GSM6893375 vehicle treated APOB-/- organoids from donor 1
GSM6893376 DGAT2i treated APOB-/- organoids from donor 1
Relations
BioProject PRJNA915399

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Supplementary file Size Download File type/resource
GSE221705_processed_raw_data_HendriksArtegianiClevers.csv.gz 696.5 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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